Cerebral glioma and cerebrovascular dysregulation are commonly associated at the micro-scale, as evidenced by neurovascular uncoupling, etc. A recent Chinese study proposed a link between glioma malignancy rating and hemodynamic dysregulation by extrapolating these microvascular alterations to the macro level for radiographic assessment.

The origins of systemic low frequency oscillations (sLFO) are not physiologically understood, but they can reliably model cerebrovascular dynamics via time-shift analysis (TSA) of blood-oxygenation level signal.

The study was conducted over five years with an n=96, (age range of 20-73yrs, mean=42). TSA was used to compare 40 healthy control brains to the study population’s affected and contralateral hemispheres. Means were calculated via Mann-Whitney U, and a predictive model was developed according to the World Health Organization’s malignancy gradation.   

The study showed that increasing malignancy correlated with increasing cerebrovascular dysregulation across both hemispheres, and the predictive model returned 91% accuracy.

As a cerebrovascular device supplier, Transonic congratulates the researchers on their results, and we look forward to further study.