OEM & Life Science Research news and insights from Transonic

Delivering Medtech Evolution: TherOx Supersaturation O2 Therapy

Written by Transonic Staff | Oct 7, 2025 5:00:00 PM

Our personal evolution is a pile of moments (birth, driver’s license, graduation, etc). Medical technology evolves the same way—an accretion of experiences and discoveries. But in both personal life and medicine, some moments aren’t pleasant, like those following a heart attack. Unfortunately, those moments can also make the difference between life and death. The deciding factor is a single molecule: O2 

This is why Zoll Medical has developed the TherOx SS02 (Super Saturated Oxygen Therapy). Following a heart attack, doctors will often use stenting to reopen coronary flow. However, a large portion of the heart’s blood supply is delivered by microvasculature which often remains blocked due to inflammation.  This creates a maddening (and deadly) clinical triangle. Lack of blood flow (02 delivery) caused the MI, which in turn causes inflammation, which further restricts blood flow.  

Zoll’s solution is supersaturated oxygen diffusion, given in an hour-long infusion.  Fundamentally, TherOx consists of a management console, an intermix cartridge, and a catheter. The entire system requires nothing more from the hospital than a standard oxygen tank and normal saline. From these, the cartridge supersaturates the saline with oxygen and delivers it to the catheter, which in turn infuses it into the patient’s blood in the left main coronary artery. This site-specific delivery passively diffuses oxygen into the microvasculature, helping to relieve inflammation, deliver oxygen to the starved heart tissue, and ultimately helping to restore microvascular flow. For metering solution delivery, Zoll needed the most accurate, reliable flow measurement in the business, so they turned to Transonic. Our flow sensors are OEM inside every TherOx SS02 

Zoll has taken the most basic need of all aerobic life, from protozoa to human beings, and extrude-honed it into a cutting-edge therapy. Transonic is proud to be OEM inside every TherOx SSO2, because medical evolution is razor-edged. It cuts away the frivolous and the unnecessary, leaving clean advancement. That’s progress. That’s Zoll, with a little help from Transonic.